糖尿病是现今生活的一种常见慢性病，长期高血糖容易造成细小血管的损伤和免疫能力低下，进一步导致糖尿病人容易遭受细菌感染并久治不愈。传统抗生素的过度使用滥用引起新型耐药细菌的出现和细菌感染加重。银作为古老而传统的广谱抗菌材料且不易产生细菌耐药已受到广泛关注。与普通银相比，近年来兴起的银纳米颗粒显著增强的抗菌能力和明显降低的生物毒性已在生物材料、生物医学等领域广泛研究和使用。但常规方法得到的Ag NPs极易团聚不仅降低了其临床应用效果，长期高浓度使用也容易引起的细胞毒性。
565net必赢官方网刘斌副教授课题组针对纳米银材料的团聚和抗菌效能问题，创造性的将银纳米粒子镶嵌在具有良好光热性能的普鲁士蓝纳米复合物表面，构建了一种双模式纳米抗菌复合物，结合近红外光激光照射技术，有效地促进了糖尿病小鼠多药耐药菌感染伤口的快速愈合。体外研究显示：这种联合抗菌策略通过破坏细胞完整性、产生ROS、降低ATP、氧化GSH等途径发挥抗多药耐药菌MRSA作用；体内实验表明：该策略通过减轻局部炎症反应和诱导创面血管内皮生长因子表达来促进MRSA感染的糖尿病创面愈合。研究结果以论文形式发表在生物材料Top期刊Biomaterials（10.1016/j.biomaterials.2020.119936），并已同步申请专利（CN201911347212.6），为后续产品研发奠定了坚实的基础。论文第一单位为565net必赢官方网，第一作者为565net必赢官方网童春义副教授、湖南师范大学钟祥华硕士生和杨粤军教授，565net必赢官方网刘斌副教授和湖南中医药大学王炜教授为并列通讯作者。
近年来，该研究团队在刘斌博士的带领下，围绕新型纳米生物材料在抗肿瘤、抗菌领域和天然药物靶向筛选领域中的应用开展了较系统的研究，得到了一系列具有重要理论价值和应用前景的研究工作，在Biomaterials、Analytical Chemistry、Chemical Communications、Nanomedicine、Biomaterials Science、Science Bulletin等权威期刊发表论文30多篇。
附：研究小组在生物医药领域发表的相关研究论文：
1.Tong Chunyi; Zhong Xianghua; Yang Yuejun; Liu Xu; Zhong Guowei; Xiao Chang;Liu Bin;Wang Wei; Yang Xiaoping. PB@PDA@Ag nanosystem for synergistically eradicating MRSA and accelerating diabetic wound healing assisted with laser irradiation.Biomaterials, 2020,DOI:10.1016/j.biomaterials.2020.119936.
2.Liu Bin; Wang Wenmiao; Fan Jialong; Long Ying; Xiao Feng; Daniyal Muhammad; Tong Chunyi; Xie Qian; Jian Yuqing; Li Bin; Ma Xiaochi; Wang Wei.RBC membrane camouflaged prussian blue nanoparticles for gamabutolin loading and combined chemo/photothermal therapy of breast cancer.Biomaterials, 2019, DOI: 10.1016/j.biomaterials.2019.119301.
3.Tong Chunyi; Li Li; Xiao Feng; Fan Jialong; Zhong Xianghua; Liu Xuanming;Liu Bin; Wu Zhaohui; Zhou Jianqun.Daptomycin and AgNP co-loaded rGO nanocomposites for specific treatment of Gram-positive bacterial infection in vitro and in vivo.Biometerials Science,2019,7: 5097-5111.
4.Li Zhen; Fan Jialong; Tong Chunyi; Zhou Hongyan; Wang Wenmiao; Li Bin;Liu Bin; Wang Wei. A smart drug-delivery nanosystem based on carboxylated graphene quantum dots for tumor-targeted chemotherapy.Nanomedicine, 2019,14:2011-2025.
5.Tong Chunyi; Zhang Xizhi; Fan Jialong; Li Bin;Liu Bin; Daniyal Muhammad; Wang Wei. PEGylated mBPEI-rGO nanocomposites facilitate hepotocarcinoma treatment combining photothermal therapy and chemotherapy.Science Bulletin, 2018, 63:935-946.
6.Tong Chunyi; Zou Wei; Ning Weimin; Fan Jialong; Li Li;Liu Bin; Liu Xuanming. Synthesis of DNA-guided silver nanoparticles on a graphene oxide surface: enhancing the antibacterial effect and the wound healing activity.RSC Advances, 2018,8:28238-28248.
7. Muhammad Daniyal, Jian YuQing, XiaoFeng, Sheng Wenbing, Fan Jialong, Xiao Chang, Wang Zhou,Liu Bin, Peng Caiyun , Qin Yuhui, Wang Wei .Development of a nanodrug-delivery systemcamouflaged by erythrocytes membrane forthe chemo/phototherapy of cancer.Nanomedicine,2020，DOI：10.2217/nnm-2019-0454.
